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Product Name
PI3 Kinase p110 alpha Mouse mAb
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Gene ID
5290
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SwissProt ID
P42336
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Gene Name
PIK3CA
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Alternative Names
phosphatidylinositol-4; 5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; PI3-kinase p110 alpha; PI3K; PI3K p110-alpha; PK3CA; PtdIns-3-kinase p110
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Background
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.
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Research Field
Signal Transduction
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Product Categories
Pathological antibody
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Host
Mouse
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Reactivity
Human
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Application
IHC-P
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Dilution Ratio
IHC: 1/100-1/500
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
3C1-6F9-6C4
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Isotype
IgG1
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Immunogen
Synthesized peptide derived from human PIK3CA H1047R
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.