-
Product Name
PBX1 Mouse mAb
-
Gene ID
5087
-
SwissProt ID
P40424
-
Gene Name
PBX1
-
Alternative Names
PBX1;PRL; Pre-B-cell leukemia transcription factor 1; Homeobox protein PBX1; Homeobox protein PRL
-
Background
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar
-
Research Field
Epigenetics and Nuclear Signaling
-
Product Categories
Pathological antibody
-
Host
Mouse
-
Reactivity
Human
-
Application
IHC-P
-
Dilution Ratio
IHC: 1/50-1/100
-
Molecular Weight
-
-
Clonality
Monoclonal Antibody
-
Clonality No.
ZN110
-
Isotype
IgG1
-
Immunogen
Full length human recombinant protein of human PBX1(NP_002576) produced in HEK293 cell.
-
Purification
Affinity Chromatography
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.