-
Product Name
KMT6 Rabbit mAb
-
Gene ID
2146
-
SwissProt ID
Q15910
-
Gene Name
EZH2
-
Alternative Names
WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2
-
Background
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
-
Research Field
Epigenetics and Nuclear Signaling
-
Product Categories
Pathological antibody
-
Host
Rabbit
-
Reactivity
Human
-
Application
IHC-P
-
Dilution Ratio
IHC: 1/100-1/200
-
Molecular Weight
-
-
Clonality
Monoclonal Antibody
-
Clonality No.
R07-4D4
-
Isotype
IgG
-
Immunogen
A synthesized peptide derived from human KMT6.
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.