货号： R50223
别名： IGF2BP3;IMP3, KOC1, VICKZ3;IGF-II mRNA-binding protein 3;KH domain-containing protein overexpressed in cancer (hKOC);VICKZ family member 3;
应用： IHC-P
反应种属： Human
目录价格：
RMB(含税报价)
数量： - + （库存件）
查看代理商 预计货期：3-4个工作日 说明书PDF
产品详情
  • Product Name
    IMP3 Rabbit mAb
  • Gene ID
    10643
  • SwissProt ID
    O00425
  • Gene Name
    IMP-3
  • Alternative Names
    IGF2BP3;IMP3, KOC1, VICKZ3;IGF-II mRNA-binding protein 3;KH domain-containing protein overexpressed in cancer (hKOC);VICKZ family member 3;
  • Background
    RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152).
  • Research Field
    Epigenetics and Nuclear Signaling
  • Product Categories
    Pathological antibody
  • Host
    Rabbit
  • Reactivity
    Human
  • Application
    IHC-P
  • Dilution Ratio
    IHC: 1/100-1/200
  • Molecular Weight
    -
  • Clonality
    Monoclonal Antibody
  • Clonality No.
    R06-3V1
  • Isotype
    IgG
  • Immunogen
    A synthesized peptide derived from human IMP3.
  • Purification
    Affinity Purified
  • Conjugation
    Unconjugated
  • Modification
    Unmodified
  • Form
    Liquid
  • Buffer System
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。
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