货号： RB20179UC
别名： S100A12,Protein S100-A12,CGRP,Calcium-binding protein in amniotic fluid 1 (CAAF1),Calgranulin-C (CAGC),Extracellular newly identified RAGE-binding protein (EN-RAGE),Migration inhibitory factor-related protein 6 (MRP-6; p6),Neutrophil S100 protein,S100 calcium-binding protein A12
应用： ELISA
反应种属： Human
目录价格：
RMB(含税报价)
数量： - + （库存件）
查看代理商 预计货期：3-4个工作日 说明书PDF
产品详情
  • Product Name
    S100A12/CGRP Rabbit mAb,capture(PBS Only)
  • Gene ID
    6283
  • SwissProt ID
    P80511
  • Gene Name
    S100A12
  • Alternative Names
    S100A12,Protein S100-A12,CGRP,Calcium-binding protein in amniotic fluid 1 (CAAF1),Calgranulin-C (CAGC),Extracellular newly identified RAGE-binding protein (EN-RAGE),Migration inhibitory factor-related protein 6 (MRP-6; p6),Neutrophil S100 protein,S100 calcium-binding protein A12
  • Background
    S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
  • Research Field
    Immunology
  • Product Categories
    Antibody Pair
  • Host
    Rabbit
  • Reactivity
    Human
  • Application
    ELISA
  • Dilution Ratio
    Determined by end user
  • Molecular Weight
    -
  • Clonality
    Monoclonal Antibody
  • Clonality No.
    R93-1A-3
  • Isotype
    IgG
  • Immunogen
    Recombinant protein
  • Purification
    Affinity Purified
  • Conjugation
    Unconjugated
  • Modification
    Unmodified
  • Form
    Liquid
  • Buffer System
    0.01M PBS, pH 7.2
  • Storage
    Store at 4°C for at least 12 months. Avoid freeze/thaw cycles
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。
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