货号： PD201059
别名： TNFSF11; OPGL; RANKL; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; NF-related activation-induced cytokine (TRANCE)
应用： Functional Assay
反应种属： -
目录价格：
RMB(含税报价)
数量： - + （库存件）
查看代理商 预计货期：3-4个工作日 说明书PDF
产品详情
  • Product Name
    Human RANKL Protein
  • Gene ID
    8600
  • SwissProt ID
    O14788
  • Gene Name
    TNFSF11
  • Alternative Names
    TNFSF11; OPGL; RANKL; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; NF-related activation-induced cytokine (TRANCE)
  • Background
    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
  • Research Field
    Immunology
  • Product Categories
    Protein
  • Host
    E-coli
  • Reactivity
    -
  • Application
    Functional Assay
  • Dilution Ratio
    -
  • Molecular Weight
    -
  • Clonality
    -
  • Clonality No.
    -
  • Isotype
    -
  • Immunogen
    -
  • Immunogen Alternative Names
    -
  • Purification
    Affinity Purified
  • Conjugation
    Unconjugated
  • Modification
    His
  • Form
    lyophilized
  • Buffer System
    0.01M PBS, pH 7.2
  • Storage
    Aliquot and store at -80°C for long term. Avoid freeze/thaw cycles.
  • Target
    -
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。
引用文献 更多完整详情
用户反馈
    推荐排序
  • 最近评价
  • 推荐排序
产品评论
评论内容：
商品评分
  • ★
  • ★
  • ★
  • ★
  • ★
微信扫码关注
Copyright ©2022 - 2023 成都正能生物技术有限责任公司
蜀ICP备13012294号-2
川公网安备 51012202001504号
  网站地图
犀牛云提供企业云服务