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Product Name
CDK8 Rabbit mAb
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Gene ID
1024
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SwissProt ID
P49336
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Gene Name
CDK8
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Alternative Names
Cyclin-dependent kinase 8
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Background
Cyclin-dependent kinase 8 (CDK8) is a cell cycle regulator, which can activate cyclin C, act in the G1/S phase, and regulate the normal cell cycle. CDK8 together with Cyclin, Med12 and Med13 form an intermediary complex, which is widely involved in the transmission of information between RNA polymerase II and gene-specific transcription factors, which can activate and inhibit transcription. In addition, CDK8 can activate a variety of signal transduction pathways such as Wnt/β-catenin and Notch, thereby inducing the occurrence and metastasis of malignant tumors such as rectal cancer and melanoma. Recent studies have found that blocking the activity of CDK8 gene can greatly reduce the glucose utilization rate of cancer cells.
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Research Field
Cell Biology
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Product Categories
Recombinant Rabbit Monoclonal antibody
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Host
Rabbit
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Reactivity
Human,Mouse
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Application
IHC-P
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Dilution Ratio
IHC-P：1/50-1/100
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Molecular Weight
Calculated MW: 53 kDa; Observed MW:55 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R07-7H-4
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Isotype
IgG
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Immunogen
Peptide
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Purification
Protein A
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS, Glycerol and BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.