-
Product Name
AMPK beta 1 Rabbit mAb
-
Gene ID
5564
-
SwissProt ID
Q9Y478
-
Gene Name
PRKAB1
-
Alternative Names
AMPK, PRKAB1
-
Background
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
-
Research Field
Cell Biology
-
Product Categories
Recombinant Rabbit Monoclonal antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse,Rat
-
Application
WB,IHC-P
-
Dilution Ratio
WB：1/500-1/1000 IHC-P：1/50-1/100
-
Molecular Weight
Calculated MW: 40 kDa; Observed MW:40 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R06-5R-5
-
Isotype
IgG/Kappa
-
Immunogen
Peptide
-
Purification
Protein G
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Liquid in PBS, Glycerol and BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.