-
Product Name
CSF-1R Rabbit mAb
-
Gene ID
1436
-
SwissProt ID
P07333
-
Gene Name
CSF1R
-
Alternative Names
CSF-1R, M-CSF-R, CD115, CSF1R, FMS
-
Background
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion.
-
Research Field
Cell Biology
-
Product Categories
Recombinant Rabbit Monoclonal antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse
-
Application
IHC-P
-
Dilution Ratio
IHC-P：1/50-1/100
-
Molecular Weight
Calculated MW: 109 kDa; Observed MW:109 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R08-1R-8
-
Isotype
IgG
-
Immunogen
Peptide
-
Purification
Protein A
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Liquid in PBS, Glycerol and BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.