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Product Name
NUMB Rabbit mAb
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Gene ID
8650
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SwissProt ID
P49757
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Gene Name
NUMB
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Alternative Names
NUMB; Protein numb homolog; h-Numb; Protein S171
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Background
Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling.
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Research Field
Neuroscience
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Product Categories
Recombinant Rabbit Monoclonal antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 71 kDa; Observed MW: 71 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-5B6
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human NUMB
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.