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Product Name
Bax Rabbit mAb
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Gene ID
581
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SwissProt ID
Q07812
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Gene Name
BAX
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Alternative Names
Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4
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Background
Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.
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Research Field
Cell Biology
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Product Categories
Recombinant Rabbit Monoclonal antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat,Hamster
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Application
WB,IHC-P,FC,IP
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Cited
WB (Pig,Duck,Chicken,Helicoverpa zea); IF (Human)
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/50 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 21 kDa; Observed MW: 21 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R07-4G1
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Bax
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.