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Product Name
AF10 Rabbit mAb
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Gene ID
8028
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SwissProt ID
P55197
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Gene Name
MLLT10
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Alternative Names
MLLT10; AF10; Protein AF-10; ALL1-fused gene from chromosome 10 protein
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Background
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Recombinant Rabbit Monoclonal antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,IHC-P
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100
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Molecular Weight
Calculated MW: 113 kDa; Observed MW: 140 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R07-2G2
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Isotype
IgG
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Immunogen
Recombinant protein of human AF10
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.