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Product Name
KDM1B Rabbit mAb
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Gene ID
221656
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SwissProt ID
Q8NB78
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Gene Name
KDM1B
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Alternative Names
AOF1; KDM1B; LSD2; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2
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Background
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Recombinant Rabbit Monoclonal antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,ICC/IF,FC,IP
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/60 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 92 kDa; Observed MW: 92 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-5J5
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human LSD2 / AOF1
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.