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Product Name
Phospho-HSF1 (Ser326) Rabbit mAb
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Gene ID
3297
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SwissProt ID
Q00613
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Gene Name
HSF1
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Alternative Names
HSF1; HSTF 1; HSTF1; Heat shock factor protein 1; Heat shock transcription factor 1;
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Background
Heat shock transcription factors (HSF, also designated HSTF) 1 and 2 are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development, and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway.
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Research Field
Tags & Cell Markers
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Product Categories
Recombinant Rabbit Monoclonal antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,IHC-P,ICC/IF,FC,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 IF: 1/50-1/200 IP: 1/50 FC: 1/50
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Molecular Weight
Calculated MW: 57 kDa;Observed MW:82kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R77-7H-8
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Phospho-HSF1 (S326)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.