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Product Name
Phospho-JAK2 (Tyr1007/1008) Rabbit mAb
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Gene ID
3717
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SwissProt ID
O60674
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Gene Name
JAK2
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Alternative Names
JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
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Background
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.
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Research Field
Cell Biology
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Product Categories
Recombinant Rabbit Monoclonal antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P,ICC/IF,FC,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 131 kDa; Observed MW: 131 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R02-1C5
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Phospho-JAK2 (Y1007 + Y1008)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.