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Product Name
Phospho-TrkB (Tyr817) Rabbit mAb
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Gene ID
4915
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SwissProt ID
Q16620
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Gene Name
NTRK2
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Alternative Names
NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
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Background
The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA.
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Research Field
Neuroscience
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Product Categories
Recombinant Rabbit Monoclonal antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P,ICC/IF,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/30
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Molecular Weight
Calculated MW: 92 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R06-7O2
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Phospho-TrkB (Y817)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.