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Product Name
Rat Anti-Mouse CD200 mAb (APC)
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Gene ID
17470
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SwissProt ID
O54901
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Gene Name
Mouse CD200
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Alternative Names
OX-2 membrane glycoprotein; OX-2; MRC
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Background
CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells,B cells,and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages.CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues.CD200 is the ligand for CD200 receptor (CD200R).The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity.Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.
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Research Field
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Product Categories
Flowcytometry
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Host
Rat
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Reactivity
Mouse
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Application
FC
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Dilution Ratio
FC: 5μL per test for million cells or whole blood in 100 μL volume.
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
OX-90
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Isotype
IgG2a
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Immunogen
A synthesized peptide derived from Mouse CD200
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Purification
Affinity Purified
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Conjugation
APC
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS with 0.05% Proclin300, 1% BSA
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Storage
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.