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Product Name
Rat Anti-Mouse CD274/PD-L1 mAb (FITC)
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Gene ID
60533
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SwissProt ID
Q9EP73
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Gene Name
Mouse PD-L1
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Alternative Names
B7-H1; PD-L1; Programmed cell death ligand 1; B7 homolog 1; B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1
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Background
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
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Research Field
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Product Categories
Flowcytometry
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Host
Rat
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Reactivity
Mouse
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Application
FC
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Dilution Ratio
FC: 5μL per test for million cells or whole blood in 100 μL volume.
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
10F.9G2
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Isotype
IgG2b
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Immunogen
A synthesized peptide derived from Mouse PD-L1
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Purification
Affinity Purified
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Conjugation
FITC
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS with 0.05% Proclin300, 1% BSA
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Storage
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.