-
Product Name
Rat Anti-Mouse IL-17A mAb (AF647)
-
Gene ID
16171
-
SwissProt ID
Q62386
-
Gene Name
Mouse IL-17A
-
Alternative Names
Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; CTLA8
-
Background
IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.
-
Research Field
-
-
Product Categories
Flowcytometry
-
Host
Rat
-
Reactivity
Mouse
-
Application
FC
-
Dilution Ratio
FC: 5μL per test for million cells or whole blood in 100 μL volume.
-
Molecular Weight
-
-
Clonality
Monoclonal Antibody
-
Clonality No.
TC11-18H10.1
-
Isotype
IgG1
-
Immunogen
A synthesized peptide derived from Mouse IL-17A
-
Purification
Affinity Purified
-
Conjugation
AF647
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Liquid in PBS with 0.05% Proclin300, 1% BSA
-
Storage
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.