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Product Name
Mouse Anti-Human CD107a/LAMP-1 mAb (AF488)
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Gene ID
3916
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SwissProt ID
P11279
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Gene Name
LAMP1
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Alternative Names
LAMP1; Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A; CD107a
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Background
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+T cell and NK cell cytotoxicity.
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Research Field
Neuroscience
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Product Categories
Flowcytometry
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Host
Mouse
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Reactivity
Human
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Application
FC
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Dilution Ratio
FC: 5μL per test for million cells or whole blood in 100 μL volume.
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
H4A3
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Isotype
IgG1
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Immunogen
A synthesized peptide derived from Human CD107a/LAMP-1
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Purification
Affinity Purified
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Conjugation
AF488
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS with 0.05% Proclin300, 1% BSA
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Storage
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.