-
Product Name
Rat Anti-Mouse CD103 mAb (AF488)
-
Gene ID
16407
-
SwissProt ID
Q60677
-
Gene Name
Mouse CD103
-
Alternative Names
Integrin alpha-E; Itgae; Integrin alpha M290; CD103
-
Background
CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
-
Research Field
-
-
Product Categories
Flowcytometry
-
Host
Rat
-
Reactivity
Mouse
-
Application
FC
-
Dilution Ratio
FC: 5μL per test for million cells or whole blood in 100 μL volume.
-
Molecular Weight
-
-
Clonality
Monoclonal Antibody
-
Clonality No.
M290
-
Isotype
IgG2a
-
Immunogen
A synthesized peptide derived from Mouse CD103
-
Purification
Affinity Purified
-
Conjugation
AF488
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Liquid in PBS with 0.05% Proclin300, 1% BSA
-
Storage
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.