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Product Name
Rat Anti-Mouse CD150 mAb (APC)
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Gene ID
27218
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SwissProt ID
Q9QUM4
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Gene Name
Mouse CD150
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Alternative Names
Slam; Slamf1; CD 150; Signaling lymphocytic activation molecule
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Background
CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.
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Research Field
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Product Categories
Flowcytometry
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Host
Rat
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Reactivity
Mouse
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Application
FC
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Dilution Ratio
FC: 5μL per test for million cells or whole blood in 100 μL volume.
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
TC15-12F12.2
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Isotype
IgG2a
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Immunogen
A synthesized peptide derived from Mouse CD150
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Purification
Affinity Purified
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Conjugation
APC
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS with 0.05% Proclin300, 1% BSA
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Storage
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.