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Product Name
Rat Anti-Mouse CD366/Tim-3 mAb (PE)
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Gene ID
171285
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SwissProt ID
Q8VIM0
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Gene Name
Mouse CD366/Tim-3
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Alternative Names
TIM3; TIMD3; HAVcr-2; TIMD-3
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Background
CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.
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Research Field
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Product Categories
Flowcytometry
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Host
Rat
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Reactivity
Mouse
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Application
FC
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Dilution Ratio
FC: 5μL per test for million cells or whole blood in 100 μL volume.
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
RMT3-23
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Isotype
IgG2a
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Immunogen
A synthesized peptide derived from Mouse CD366/Tim-3
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Purification
Affinity Purified
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Conjugation
PE
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS with 0.05% Proclin300, 1% BSA
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Storage
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.