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Product Name
Mouse Anti-Rat CD45 mAb (FITC)
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Gene ID
24699
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SwissProt ID
P04157
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Gene Name
Rat CD45
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Alternative Names
Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; LCA; T200; Ly-5; Ptprc
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Background
CD45 is a 180-220 kD protein also known as leukocyte common antigen (LCA). It is a protein tyrosine phosphatase with multiple isoforms differing as a result of alternative splicing of the extracellular domain and glycosylation. CD45 is expressed on all hematopoietic cells except erythrocytes and platelets; isoform expression depends on cell type, activation state, and cell maturation. CD45 functions in signal transduction through T and B cell antigen receptors. CD45 has been shown to interact with various proteins including galectin-1, CD2, CD3, and CD4. The OX-1 antibody has been shown to partially inhibit NK cell-mediated lysis of syngeneic tumor cellsin vitro.
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Research Field
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Product Categories
Flowcytometry
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Host
Mouse
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Reactivity
Rat
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Application
FC
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Dilution Ratio
FC: 5μL per test for million cells or whole blood in 100 μL volume.
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
OX-1
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Isotype
IgG1
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Immunogen
A synthesized peptide derived from Rat CD45
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Purification
Affinity Purified
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Conjugation
FITC
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS with 0.05% Proclin300, 1% BSA
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Storage
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.