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Product Name
EGFR(E746-A750 Mutant)del Mouse mAb
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SwissProt ID
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Gene Name
EGFR,HER1,ERBB1
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Alternative Names
EGFR,HER1,ERBB1
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Background
EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR).
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Vertebrates
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Application
WB, ELISA
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Dilution Ratio
ELISA: 1/1000-1/5000,WB: 1/500-1/1000
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Clonality
Monoclonal Antibody
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Clonality No.
3E3-P5-R2
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Immunogen
A synthetic peptide from the internal region of EGFR which includes the deletion of E746-A750, human origin.
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Purification
Purified from ascites
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
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Storage
Store at -20°C. Avoid repeated freezing and thawing