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Product Name
FBXW7(R479L Mutant) Mouse mAb
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SwissProt ID
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Gene Name
FBW6, FBW7, FBXW7, FBX30, CDC4, SEL10
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Alternative Names
FBW6, FBW7, FBXW7, FBX30, CDC4, SEL10
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Background
F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. Mutations in this gene are detected in ovarian, breast and colorectal cancer cell lines, implicating the gene’s potential role in the pathogenesis of human cancers.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Vertebrates
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Application
WB, ELISA
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Dilution Ratio
ELISA: 1/1000-1/5000 WB: 1/500-1/1000
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Clonality
Monoclonal Antibody
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Clonality No.
3W8-J3-B1
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Isotype
IgG
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Immunogen
A synthetic peptide from the internal region of FBXW7 which includes the mutation of R479L, human origin.
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Purification
Purified from ascites
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
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Storage
Store at -20°C. Avoid repeated freezing and thawing