-
Product Name
IDH1(R132H Mutant) Mouse mAb
-
SwissProt ID
-
Gene Name
IDH1
-
Alternative Names
IDH1
-
Background
Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Mutations of Arg-132 in IDH to Cys, His, Leu or Ser abolish magnesium binding and the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R-2-hydroxyglutarate. Elevated levels of R-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
-
Research Field
Signal Transduction
-
Product Categories
Primary antibody
-
Host
Mouse
-
Reactivity
Vertebrates
-
Application
WB, IHC-P, ICC/IF,ELISA
-
Dilution Ratio
ELISA: 1/1000-1/5000,WB: 1/100-1/1000,ICC/IF: 1/50-1/100,IHC-P: 1/50-1/100
-
Clonality
Monoclonal Antibody
-
Clonality No.
1X8-B1-R3
-
Isotype
IgG
-
Immunogen
Recombinant protein of human IDH1 which includes the mutation of R132H.
-
Purification
Purified from ascites
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
PBS (without Mg 2+ and Ca 2+ ), pH 7.4, 150 mM NaCl, 50% glycerol
-
Storage
Store at -20°C. Avoid repeated freezing and thawing