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Product Name
IDH2(R172G Mutant) Mouse mAb
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SwissProt ID
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Gene Name
IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH
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Alternative Names
IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH
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Background
Isocitrate dehydrogenase (IDH) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. The isocitrate and isopropylmalate dehydrogenases family has three members, IDH1, IDH2 and IDH3. IDH2 plays a role in intermediary metabolism and energy production. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2). Somatic mosaic mutations of this protein have also been found associated to Ollier disease and Maffucci syndrome, and R172G IDH2 mutations do exist in diffusely infiltrative gliomas.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Vertebrates
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Application
WB, IHC-P, ICC/IF, ELISA
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Dilution Ratio
ELISA: 1/1000-1/5000,WB: 1/100-1/1000,ICC/IF: 1/50-1/100,IHC-P: 1/50-1/100
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Clonality
Monoclonal Antibody
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Clonality No.
2D9-D6-Y9
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Isotype
IgG
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Immunogen
A synthetic peptide from the internal region of IDH2 which includes the mutation of R172G, human origin.
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Purification
Purified from ascites
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
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Storage
Store at -20°C. Avoid repeated freezing and thawing