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Product Name
Cleaved-Caspase 6 p18 Rabbit pAb
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Gene ID
839
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SwissProt ID
P55212
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Gene Name
CASP6
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Alternative Names
CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2
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Background
Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes. Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Rat
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Application
WB,IHC-P,ELISA
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000
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Molecular Weight
Calculated MW: 33 kDa; Observed MW: 20,35 kDa
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 6.
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Cleaved
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Form
Liquid
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.