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货号： 347345

别名： IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB

应用： WB,IHC-P,ELISA

反应种属： Human,Mouse,Rat,Monkey

目录价格：

RMB(含税报价)

数量： - + （库存件）

查看代理商预计货期：3-4个工作日说明书PDF

产品详情

Product Name

Phospho-IKK beta (Tyr188) Rabbit pAb
Gene ID

3551
SwissProt ID

O14920
Gene Name

IKBKB
Alternative Names

IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB
Background

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3). Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits.
Research Field

Signal Transduction
Product Categories

Primary antibody
Host

Rabbit
Reactivity

Human,Mouse,Rat,Monkey
Application

WB,IHC-P,ELISA
Dilution Ratio

WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000
Molecular Weight

Calculated MW: 87 kDa; Observed MW: 87 kDa
Clonality

Polyclonal Antibody
Clonality No.

-
Isotype

IgG
Immunogen

The antiserum was produced against synthesized peptide derived from human IKK-beta around the phosphorylation site of Tyr188.
Purification

Affinity Chromatography
Conjugation

Unconjugated
Modification

Phosphorylated
Form

Liquid
Buffer System

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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验证详情

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应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。

引用文献更多完整详情

标题： Forsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling

样本种属： Rat

杂志： Drug Design Development and Therapy

应用： WB

IF： 4.8

文献链接