-
Product Name
Caspase 3 Mouse mAb
-
Gene ID
836
-
SwissProt ID
P42574
-
Gene Name
CASP3
-
Alternative Names
CPP32; SCA-1; CPP32B
-
Background
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
-
Research Field
Cell Biology
-
Product Categories
Primary antibody
-
Host
Mouse
-
Reactivity
Human,Mouse,Rat
-
Application
WB,ELISA
-
Dilution Ratio
WB: 1/500-1/1000 ELISA: 1/10000
-
Molecular Weight
Calculated MW: 32kDa;Observed MW: 32kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
6L2-V1-S1
-
Isotype
Mouse IgG1
-
Immunogen
Purified recombinant fragment of human CASP3 expressed in E. Coli.
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Purified antibody in PBS with 0.05% sodium azide
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.