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Product Name
IL-10 Receptor alpha Mouse mAb
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Gene ID
3587
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SwissProt ID
Q13651
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Gene Name
CD210
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Alternative Names
IL10RA; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1
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Background
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
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Research Field
Immunology
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
ICC/IF,FC,ELISA
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Dilution Ratio
IF: 1/50-1/200 FC: 1/50-1/100 ELISA: 1/10000
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
9C2-U6-E9
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Isotype
Mouse IgG1
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Immunogen
Purified recombinant fragment of human CD210 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Purified antibody in PBS with 0.05% sodium azide
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.