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Product Name
Insulin Receptor Mouse mAb
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Gene ID
3643
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SwissProt ID
P06213
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Gene Name
CD220
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Alternative Names
INSR; HHF5
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Background
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human,Mouse,Monkey
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Application
WB,ICC/IF,FC,ELISA
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 FC: 1/50-1/100 ELISA: 1/10000
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Molecular Weight
Calculated MW: 156 kDa;Observed MW: 95 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
2K1-W1-L2
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Isotype
Mouse IgG2a
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Immunogen
Purified recombinant fragment of human CD220 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Purified antibody in PBS with 0.05% sodium azide
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.