-
Product Name
Lamin A/C Mouse mAb
-
Gene ID
4000
-
SwissProt ID
P02545
-
Gene Name
LMNA
-
Alternative Names
FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1
-
Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
-
Research Field
Tags & Cell Markers
-
Product Categories
Primary antibody
-
Host
Mouse
-
Reactivity
Human,Mouse,Rat
-
Application
WB,IHC-P,ELISA
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 ELISA: 1/10000
-
Molecular Weight
Calculated MW: 74 kDa;Observed MW: 74 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
6U2-D5-M1
-
Isotype
Mouse IgG1
-
Immunogen
Purified recombinant fragment of human LMNA expressed in E. Coli.
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Ascitic fluid containing 0.03% sodium azide.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.