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Product Name
LEF1 Mouse mAb
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Gene ID
51176
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SwissProt ID
Q9UJU2
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Gene Name
LEF1
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Alternative Names
LEF-1; TCF10; TCF7L3; TCF1ALPHA
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Background
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
WB,IHC-P,ELISA
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 ELISA: 1/10000
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Molecular Weight
Calculated MW: 44 kDa;Observed MW: 44 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
3S1-L3-S7
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Isotype
Mouse IgG1
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Immunogen
Purified recombinant fragment of human LEF1 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Purified antibody in PBS with 0.05% sodium azide
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.