您现在的位置：首页 > 产品中心 > 抗体系列 > 精品一抗

货号： 347220

别名： EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300

应用： WB,IHC-F,IHC-P,ICC/IF,ELISA

反应种属： Human,Mouse,Rat

目录价格：

RMB(含税报价)

数量： - + （库存件）

查看代理商预计货期：3-4个工作日说明书PDF

产品详情

Product Name

p300 Rabbit pAb
Gene ID

2033
SwissProt ID

Q09472
Gene Name

EP300
Alternative Names

EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300
Background

EP300: E1A binding protein p300. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary antibody
Host

Rabbit
Reactivity

Human,Mouse,Rat
Application

WB,IHC-F,IHC-P,ICC/IF,ELISA
Dilution Ratio

WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000
Molecular Weight

Calculated MW: 264 kDa; Observed MW: 300 kDa
Clonality

Polyclonal Antibody
Clonality No.

-
Isotype

IgG
Immunogen

Synthesized peptide derived from the Internal region of human p300.
Purification

Affinity Purified
Conjugation

Unconjugated
Modification

Unmodified
Form

Liquid
Buffer System

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

展开更多

验证详情

展开更多

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。

引用文献更多完整详情

标题： Experimental evidence for cancer resistance in a bat species

样本种属： Mouse

杂志： Nature Communications

应用： WB

IF： 16.6

文献链接

标题： Andrographolide regulates H3 histone lactylation by interfering with p300 to alleviate aortic valve calcification

样本种属： Human

杂志： BRITISH JOURNAL OF PHARMACOLOGY

应用： WB

IF： 7.3

文献链接

标题： Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway

样本种属： Mouse

杂志： Antioxidants

应用： WB

IF： 7

文献链接