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Product Name
PARP1 Mouse mAb
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Gene ID
142
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SwissProt ID
P09874
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Gene Name
PARP
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Alternative Names
PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1
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Background
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
WB,FC
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Dilution Ratio
WB: 1/500-1/1000 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 113 kDa;Observed MW: 113 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
8X2-C6-P3
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Isotype
Mouse IgG1
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Immunogen
Synthetic peptide of human PARP, conjugated to KLH.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Ascitic fluid containing 0.03% sodium azide.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.