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Product Name
Perforin Mouse mAb
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Gene ID
5551
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SwissProt ID
P14222
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Gene Name
PRF1
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Alternative Names
P1; PFP; HPLH2
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Background
This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.
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Research Field
Immunology
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human,Mouse
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Application
WB,IHC-P,FC,ELISA
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 FC: 1/50-1/100 ELISA: 1/10000
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Molecular Weight
Calculated MW: 61 kDa;Observed MW: 61 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
5R6-W3-D5
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Isotype
Mouse IgG1
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Immunogen
Purified recombinant fragment of human PRF1 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Purified antibody in PBS with 0.05% sodium azide
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.