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Product Name
MEK4 Mouse mAb
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Gene ID
6416
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SwissProt ID
P45985
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Gene Name
MAP2K4
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Alternative Names
JNKK; MEK4; MKK4; SEK1; JNKK1; SERK1; MAPKK4; PRKMK4; MAP2K4
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Background
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues .
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
WB,IHC-P,FC,ELISA
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 FC: 1/50-1/100 ELISA: 1/10000
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Molecular Weight
Calculated MW: 44 kDa;Observed MW: 44 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
5D9-M7-I2
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Isotype
Mouse IgG1
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Immunogen
Purified recombinant fragment of human MAP2K4 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Ascitic fluid containing 0.03% sodium azide.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.