产品详情
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Product Name
NF-KB p100/p52 Mouse mAb
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Gene ID
4791
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SwissProt ID
Q00653
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Gene Name
NFKB2
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Alternative Names
p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100
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Background
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human,Mouse
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Application
WB,ELISA
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Dilution Ratio
WB: 1/500-1/1000 ELISA: 1/10000
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Molecular Weight
Calculated MW: 97 kDa;Observed MW: 97 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
2N1-U1-L4
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Isotype
Mouse IgG1
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Immunogen
Purified recombinant fragment of human NFKB2 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Purified antibody in PBS with 0.05% sodium azide
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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