产品详情
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Product Name
GRM6 Mouse mAb
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Gene ID
2916
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SwissProt ID
O15303
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Gene Name
GRM6
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Alternative Names
mGlu6; CSNB1B; GPRC1F; MGLUR6
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Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
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Research Field
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
FC,ELISA
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Dilution Ratio
FC: 1/50-1/100 ELISA: 1/10000
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
4H4-L6-W5
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Isotype
Mouse IgG1
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Immunogen
Purified recombinant fragment of human GRM6 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Purified antibody in PBS with 0.05% sodium azide
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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