产品详情
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Product Name
PRKAG3 Mouse mAb
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Gene ID
53632
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SwissProt ID
Q9UGI9
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Gene Name
PRKAG3
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Alternative Names
AMPKG3
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Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.
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Research Field
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
IHC-P,ICC/IF,ELISA
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Dilution Ratio
IHC: 1/100-1/200 IF: 1/50-1/200 ELISA: 1/10000
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
5L4-I2-M8
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Isotype
Mouse IgG1
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Immunogen
Purified recombinant fragment of human PRKAG3 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Purified antibody in PBS with 0.05% sodium azide
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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