-
Product Name
PPM1A Rabbit pAb
-
Gene ID
5494
-
SwissProt ID
P35813
-
Gene Name
PPM1A
-
Alternative Names
protein phosphatase; Mg2+/Mn2+ dependent 1A; PP2CA; PP2Calpha; PP2C-ALPHA
-
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
-
Research Field
Signal Transduction
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse,Rat
-
Application
WB,IHC-P
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100
-
Molecular Weight
Calculated MW: 42 kDa; Observed MW: 42 kDa
-
Clonality
Polyclonal Antibody
-
Clonality No.
-
-
Isotype
IgG
-
Immunogen
Fusion protein of human PPM1A
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.