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Product Name
Osteoprotegerin Mouse mAb
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Gene ID
4982
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SwissProt ID
O00300
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Gene Name
TNFRSF11B
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Alternative Names
TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin
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Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
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Research Field
Cardiovascular
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
ICC/IF,FC
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Dilution Ratio
IF: 1/50-1/200 FC: 1/50-1/100
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
5G2
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Isotype
IgG1
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Immunogen
Purified recombinant fragment of human TNFRSF11B expressed in E. Coli.
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Purification
Ascitic Fluid
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Ascitic fluid containing 0.03% sodium azide.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.