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Product Name
PSMC6 Rabbit pAb
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Gene ID
5706
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SwissProt ID
P62333
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Gene Name
PSMC6
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Alternative Names
26S protease regulatory subunit 10B; 26S proteasome AAA-ATPase subunit RPT4; Proteasome 26S subunit ATPase 6; Proteasome subunit p42; SUG2
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Background
In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S Proteasome. The 26S Proteasome is a protease complex that selectively breaks down proteins that have been modified by polyubiquitin chains. It is made up of two multisubunit complexes: the 20S Proteasome chamber, which serves as the proteolytic core of the complex and two 19S regulatory particles which recognize and unfold ubiquitinated proteins. PSMC6 (proteasome (prosome, macropain) 26S subunit, ATPase 6), also known as P44, p42, SUG2, S10B or CADP44, is a regulatory component of the 26S proteasome. More specifically, PSMC6 is one of the six ATPase subunits of the 19S regulator base. It contains a leucine zipper motif and an AAA (ATPase associated with diverse cellular activities) domain and belongs to the AAA ATPase family of chaperone-like ATPases.
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Research Field
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB, ICC/IF
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200
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Molecular Weight
Calculated MW: 44kDa
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
Synthetic peptide corresponding to Human PSMC6.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.