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Product Name
CKII alpha (5F9) Mouse mAb
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Gene ID
1459
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SwissProt ID
P19784
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Gene Name
CSNK2A2
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Alternative Names
CK2A2; CSNK2A1; FLJ43934
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Background
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinasethat is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alphaand alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits arecatalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to thealpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteinsimplicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thoughtto influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via thephosphorylation of Akt.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human,Mouse
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Application
WB,FC
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Dilution Ratio
WB: 1/500-1/1000 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 41 kDa; Observed MW: 41 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
5F9-H11-F7
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Isotype
IgG1
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Immunogen
Purified recombinant fragment of human CSNK2A2 expressed in E. Coli.
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Purification
Ascitic Fluid
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Ascitic fluid containing 0.03% sodium azide.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.