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Product Name
RUNX3 (4H2) Mouse mAb
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Gene ID
864
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SwissProt ID
Q13761
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Gene Name
RUNX3
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Alternative Names
AML2; CBFA3; PEBP2aC; FLJ34510; MGC16070
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Background
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human,Mouse
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Application
WB,IHC-P,ICC/IF,FC
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 IF: 1/50-1/200 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 44 kDa; Observed MW: 44 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
4H2-F10-A4
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Isotype
IgG2b
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Immunogen
Purified recombinant fragment of human RUNX3 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Purified antibody in PBS with 0.05% sodium azide.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.