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Product Name
Phospho-Glycogen synthase 1(Ser645) Rabbit pAb
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Gene ID
2997
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SwissProt ID
P13807
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Gene Name
GYS1
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Alternative Names
Glycogen [starch] synthase, muscle; GYS1; GYS
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Background
Glycogen is a polysaccharide of glucose and serves as an energy storage in mammalian muscle and liver. Glycogen synthase catalyzes the rate-limiting step of glycogen biosynthesis and has two major isoforms in mammals -- muscle isoform (GYS1) and liver isoform (GYS2) respectively. Glycogen synthase kinase-3α (GSK-3α) and glycogen synthase kinase-3β (GSK-3β) phosphorylate glycogen synthase at multiple sites in its C-terminus (Ser641, Ser645, Ser649 and Ser653) inhibiting its activity. Hypoxia alters glycogen metabolism including temporal changes of GYS1 expression and phosphorylation in cancer cells, suggesting the role of metabolic reprogramming of glycogen metabolism in cancer growth.
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Research Field
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Rat
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
Synthetic phosphopeptide derived from human Glycogen synthase 1 around the phosphorylation site of Serine 645.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
1 mg/ml in PBS with 0.05% sodium azide,pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.