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Product Name
Phospho-MEK7 (Ser271) Rabbit pAb
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Gene ID
5609
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SwissProt ID
O14733
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Gene Name
MAP2K7
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Alternative Names
Mitogen Activated Protein Kinase kinase 7; c-Jun N-terminal kinase kinase 2; JNK activating kinase 2; Jnkk 2; Jnkk2; MAP2K7; MAPKK-7; MKK 7; MKK-7; PRKMK 7; PRKMK7; Sek-2; Dual specificity mitogen activated protein kinase kinase 7; JNK kinase 2; Jnkk
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Background
MKK7 is a MAP kinase kinase that serves as a specific activator of the SAPK/JNK pathway. MKK7 is strongly activated by TNF-α, as well as other environmental stresses, whereas SEK1/MKK4, which activates both p38 and SAPK/JNK pathways, is not activated by TNF-α. Sequence alignment of the activation loop of the MAP kinase kinase family members indicates that Ser271 and Thr275 are potential phosphorylation sites that are crucial for the kinase acivity.
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Research Field
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
Synthetic phosphopeptide derived from human MEK-7 around the phosphorylation site of Serine 271
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
1 mg/ml in PBS with 0.05% sodium azide,pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.