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Product Name
Myotubularin Rabbit pAb
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Gene ID
560881
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SwissProt ID
Q32PM3
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Gene Name
MTM1
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Alternative Names
Myotubularin，Phosphatidylinositol-3,5-bisphosphate 3-phosphatase，Phosphatidylinositol-3-phosphate phosphatase，mtm1
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Background
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) . Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome . Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture . Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
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Research Field
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Zebrafish
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Application
WB
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Dilution Ratio
WB: 1/2000
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Molecular Weight
Calculated MW:74 kDa; Observed MW: 74 kDa
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
This DANRE mtm1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide from the region of DANRE mtm1.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS containing 0.09% sodium azide, pH 7.3.
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Storage
Store at 2-8°C for up to 2 weeks. store at -20°C for long term storage in small aliquots. Avoid freeze/thaw cycles.